Download Enzinger and Weiss's Soft Tissue Tumors 6th Edition PDF Free 37: The Essential Reference fo

The presentation along the spermatic cord in our patient had led to a misdiagnosis of inguinal hernia for several years, thus delaying tumor removal. Therefore, even though spermatic cord SFT is a rare tumor, it should be considered in the differential diagnosis of spermatic cord masses, by the clinician. Another benign mesenchymal tumor in the urogenital region that can be confused with a spermatic cord SFT is cellular angiofibroma which is typically seen in the superficial soft tissue of the genital region, with the inguinal region being the most common site in men [26]. Histologically, our tumor had some important features of a cellular angiofibroma, notably presence of florid proliferation of minute-small- to medium-sized vessels with hyalinized walls.

enzinger and weiss's soft tissue tumors 6th edition pdf free 37

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The most widely recognized predisposing factors for angiosarcomas of skin and soft tissue are radiation and chronic lymphedema (Stewart-Treves syndrome). There is also a strong association with contact to some chemical agents such as thorium dioxide, arsenic, vinyl chloride or to foreign material introduced iatrogenically like vascular graft material or by trauma such as foreign bodies [1][4].

Due to the rarity of randomized trials and prospective studies, the management guidelines for other soft tissue sarcomas tend to be utilized when dealing with angiosarcoma. According to 7th edition of AJCC Soft-Tissue Sarcoma Staging System, this case was classified as pT2bN1M0. The presence of positive nodes (N1) in M0 tumors is considered stage III.

Between 2000 and 2015, 26 genetically confirmed PPMSSs were included. The clinicopathologic features of all of the cases were reviewed. Immunohistochemical staining was carried out using the following antibodies: TLE1, cytokeratin (AE1/AE3), EMA, CD99, Bcl-2, CK7, CD34, S-100 protein, and Ki-67. The chromosomal translocation t(X;18)(p11.2;q11.2) was detected by fluorescence in situ hybridization (FISH) and reverse transcription polymerase chain reaction (RT-PCR). We compared the clinical, pathologic, immunohistochemical, and molecular features of this series with that of the previous series and soft tissue synovial sarcomas.

Synovial sarcoma (SS) is a morphologically, clinically, and genetically well-defined soft-tissue neoplasm. SSs are characterized by the t(X;18)(p11.2;q11.2) translocation, which leads to SS18-SSX gene fusion [1, 2], and extremely rare neoplasms harbor SS18L1-SSX1, resulting from t(X;20) [3, 4]. Most tumors occur in the extremities near the joints, followed by the trunk and head and neck regions [1, 2]. Primary SSs have also been reported to arise from a variety of unusual locations, such as the mediastinum, retroperitoneum, and various viscera [1, 2].

This study was approved by the West China Hospital Institutional Review Board. A SNOMED search of the hospital surgical pathology files from January 2000 to May 2015 identified 489 spindle cell tumors located in the pleuropulmonary and mediastinal area, whereas 24265 lung carcinomas were detected during this period. The tumors were reviewed by two pathologists with soft tissue tumor pathology expertise (H.Z. and H.C) and three general surgical pathologists (T.L., B.X., and T.Z). Two hundred and seventy-seven of the spindle cell tumors were sarcomas. Eighty-seven metastatic sarcomas (including 28 SSs) were excluded, and 190 of 277 spindle cells sarcomas were primary tumors. SS was the most common primary sarcoma (28/190, 14.7 %) in this location, followed by liposarcoma (14/190, 7.4 %), Ewing sarcoma (13/190, 6.8 %), leiomyosarcoma (13/190, 6.8 %), and chondrosarcoma (11/190, 5.8 %). Finally, 26 t(X;18)(p11.2;q11.2) -positive PPMSSs were included in this study.

The macroscopic descriptions were available in 18 of the 20 resected specimens. Thirteen (72.2 %) tumors were well-circumscribed and surrounded by thin fibrous pseudocapsules or unencapsulated, and the remaining five (27.8 %) tumors were poorly circumscribed. On cut sections, the tumors were white-gray to tan and soft fleshy to rubbery in texture. Twelve tumors (66.7 %) contained focal necrosis and hemorrhage. Cystic changes were observed in four cases (22.2 %). No grossly visible calcification was observed.

Detailed information regarding microscopic invasion and margins was available in 17 cases. Eight tumors infiltrated into the adjacent tissues, and the remaining nine were free of invasion. The surgical margins were negative in 14 tumors and positive in three tumors. Ten patients underwent lymph node dissections; the eight cases with available information were free of lymph node metastasis (Table 2).

Here, we present the clinicopathological and molecular features of 26 t(X;18)(p11.2;q11.2)-positive PPMSSs. These tumors seem to be more aggressive than the soft tissue counterparts and more aggressive than prior PPMSSs series. Extensive surgical resection of the tumor and more effective adjuvant therapy should be advocated. The diagnosis of PPMSS might be challenging. A combination of clinical studies, careful morphologic analysis, and a full panel of immunomarkers including TLE1 and genetic studies is helpful in confirming the diagnosis.

MO may simulate malignant bone lesions such as extra-skeletal or surface osteosarcomas, or soft tissue sarcomas such as synovial sarcoma or undifferentiated pleomorphic sarcoma. In the early phase the diagnosis of MO is challenging because imaging and histopathological findings may be non-characteristic.

Detailed medical history as well as clinical examination, follow-up imaging studies and histological assessment are crucial for a proper diagnosis. Early and accurate differential diagnosis between MO and malignant soft tissue and bone tumours is important to maximize.

There is extensive literature in case reports of MO that mimic musculoskeletal tumours. However, to the best of our knowledge, there have been limited reports addressing the clinicopathological and imaging findings of MO in comparison to other bone or soft tissue malignant tumours that emerge in the differential diagnosis of a rapid-growing muscular mass. Awareness that MO may simulate bone and soft tissue tumours can help orthopaedic surgeons in a prompt diagnosis and clinical decision making.

Female patient aged 23 years, after Covid-19 lockdown. She presented with pain at the right thigh, increasing during daily activities, after long-distance walking during lockdown. (A) An axial T2w MR image shows a predominately hyperintense mass (arrow) within the adductor longus muscle. (B) Heterogenous enhancement of the mass (arrow) and mild enhancement of the adjacent fasciae at the medial aspect of the thigh are seen on a fat-suppressed contrast-enhanced T1w MR image (arrowhead). (C) A coronal fat-suppressed contrast-enhanced T1w MR image shows a hypointense thick incomplete rim (arrow) and marked oedema of the surrounding muscle (arrowhead). The differential diagnosis included soft tissue sarcoma.

Male patient aged 16 years, without prior history of injury. (A) An axial fat-suppressed MR image shows a predominately hyperintense mass within the vastus lateralis. A target-like configuration is seen created by alternating concentric hypointense rings, presumably representing calcifications and a hypointense centre that may represent fibrosis, blood products or calcifications. (B) A coronal STIR MR image displays a spindle-like inhomogenous region that follows the orientation of the vastus lateralis, with hyperintense apices, representing muscle oedema and predominately hypointense centre. The differential diagnosis included soft tissue sarcoma. 2ff7e9595c